| Day | Date | Opponent |
Location | Time |
| Wednesday | 11/3/10 | Lawson State | Columbia, TN | 8 a.m. |
| Friday | 11/5/10 | Quality Inn Classic | Niceville, FL | 7:30 p.m. |
| Saturday | 11/6/10 | Quality Inn Classic | Niceville, FL | 7:30 p.m. |
| Friday | 11/12/10 | Volunteer State | Gallatin, TN | 8 p.m. |
| Saturday | 11/13/10 | Motlow State | Lynchburg, TN | 4 p.m. |
| Friday | 11/19/10 | Chattanooga State | Columbia, TN | 8 p.m. |
| Saturday | 11/20/10 | Cleveland State | Cleveland, TN | 4 p.m. |
| Tuesday | 11/23/10 | Gadsden State | Gadsden, AL | 8 p.m. |
| Tuesday | 11/30/10 | Gadsden State |
Columbia, TN | 8 p.m. |
| Friday | 12/3/10 | Walter's State | Morristown, TN | 8 p.m. |
| Saturday | 12/4/10 | Roane State | Harriman, TN |
4 p.m. |
| Tuesday | 12/7/10 | NW Shoals | Columbia, TN | 7:30 p.m. |
| Friday | 12/10/10 | Southwest TN | Columbia, TN | 8 p.m. |
| Saturday | 12/11/10 | Dyersburg State | Columbia, TN | 4 p.m. |
| Thursday | 1/6/11 | NW Shoals, AL | Muscle Shoals, AL | 2 p.m. |
| Saturday | 1/8/11 | NW Mississippi Community College |
Senatobia, MS | 3 p.m. |
| Saturday | 1/15/11 | Jackson State | Columbia, TN | 4 p.m. |
| Friday | 1/21/11 | Chattanooga State | Chattanooga, TN | 8 p.m. |
| Saturday | 1/22/11 | Cleveland State | Cleveland, TN | 4 p.m. |
| Friday | 2/28/11 | Walter's State | Columbia, TN | 8 p.m. |
| Saturday | 1/29/11 | Roane State |
Columbia, TN | 4 p.m. |
| Wednesday | 2/2/11 | Southwest TN |
Memphis, TN | 8 p.m. |
| Saturday | 2/5/11 | Dyersburg State | Dyersburg, TN | 4 p.m. |
| Saturday | 2/12/11 | Jackson State | Jackson, TN | 4 p.m. |
| Wednesday | 2/16/11 | Volunteer State | Columbia, TN | 8 p.m. |
| Saturday | 2/19/11 | Motlow State | Columbia, TN | 4 p.m. |
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